ICCBM-16 Programme

Prague, Hotel Pyramida, July 2-7, 2016

Programme overview - sessions (pdf)	Programme overview - speakers (pdf)
Programme detailed (pdf)

Saturday, July 2

10:00-19.00		Exhibition installation
15:00-22.00		Registration
20:00-22.00		Welcome reception

Sunday, July 3

8:30	Opening ceremony
		chair: Claude Sauter
9:00	Osamu Nureki Graduate School of Science, University of Tokio, Japan	High-resolution X-ray Crystallography of Membrane Proteins and Molecular Mechanisms of Membrane Transporters	htm	pdf

S1 - Membrane Protein Crystallization I		chair: Martin Caffrey
9:50	Eric Xu Van Andel Institute in Michigan	An X-Ray Laser Structure of Rhodopsin-Arrestin Complex	htm	pdf
10:20	Byron Carpenter Cambridge, UK	Engineering Heterotrimeric G Proteins to Facilitate Crystallisation of GPCRs in their Active Conformation	htm	pdf
10:50	Martin Caffrey Trinity College, Dublin, Ireland	New and Improved Features of the Lipid Cubic Phase (In Meso) Method for Crystallizing Membrane and Soluble Proteins and Complexes	htm	pdf
11:10	Edward Pryor Anatrace	The importance of detergent selection: Are you choosing the right detergent for your membrane protein?	htm	pdf
11:30	Break, refreshment	chair: Terese Bergfors
12:00	Naomi Chayen Imperial College, London	Enhancing the success of crystallizing biological macromolecules	htm	pdf

12:50-14.00 Lunch buffet

S2 - Crystallization of macromolecular complexes		chair: Song Tan
14:00	Anthony Kossiakoff University of Chicago, Chicago, USA	Generation of antibody-Fab reagents to capture and stabilize functionally important conformational states of proteins to facilitate their structure determination by crystallography and single particle Cryo-EM	htm	pdf
14:30	Nicolas Thoma Friedrich Miescher Institute, Basel, Switzerland	Macromolecular machines in genome maintenance	htm	pdf
15:00	Song Tan Penn State University, University Park, USA	Crystallization of chromatin complexes	htm	pdf
15:30	Seth Rubin University of California, CA, USA	X-ray Crystallography Studies of Protein Complexes Controlling Cell Cycle Gene Expression	htm	pdf
15:50	Break, refreshment

S3 - Membrane protein crystallization II		chair: Hartmut Luecke
16:20	Fei Xu iHuman Institute Shangai Tech University	New advances in structural discovery of human G protein-coupled receptors: the 826 project and importance of ligand stabilization	htm	pdf
16:50	Khyati Kapoor University of California, CA, USA	Mechanism of inhibition of hGLUT1 is conserved between cytochalasin B and phenylalanine amides	htm	pdf
17:10	Chun Jung Chen National Synchrotron Radiation Research Center Hsinchu, Taiwan	Purification and Crystallization of an Antigenic Outer-Membrane Protein from Salmonella Typhi	htm	pdf
17:30	Patrick Shaw Stewart Douglas Instruments Ltd, Hungerford, UK	Microseed matrix-screening (rMMS): introduction, theory, practice and a new technique for membrane protein crystallization in LCP	htm	pdf

18:00 - 19:30		Poster session I

Monday, July 4

S4 - Automation in crystallization		chair: Janet Newman
8:30	Jose A. Marquez EMBL Grenoble Outstation, France	Automated crystal mounting and processing through laser photoablation. New opportunities for integrated macromolecular crystallography pipelines	htm	pdf
9:00	Moritz Hunkeler University of Basel, Switzerland	Advanced Imaging in Lab-Scale Protein Crystallization	htm	pdf
9:30	Carien Dekker Novartis, Basel, Switzerland	TeXRank: Texture Image Analysis and Machine Learning for Crystallizing Difficult Proteins	htm	pdf
10:00	Charline Gerard CINaM - CNRS, Aix-Marseille Université	Microfluidic platform for optimisation of crystallisation conditions	htm	pdf
10:20	Jochen Müller-Dieckmann Formulatrix	Advancements in Automated Imaging	htm	pdf
10:40	Break, refreshment

S5 - Crystallization approaches for serial crystallography		chair: Christian Betzel
11:10	Dominik Oberthuer Center for Free-Electron Laser Science, Hamburg	Changing concepts: Crystallization for serial and time-resolved crystallography	htm	pdf
11:40	Robert Dods University of Gothenburg, Sweden	Micro-crystallisation of Photosynthetic Reaction Center for Time-Resolved Serial Femtosecond Crystallography at an X-ray Free Electron Laser	htm	pdf
12:10	Jason Stagno National Cancer Institute, Frederick, MD, USA	Advantages of Serial Femtosecond Crystallography for RNA Structure Determination	htm	pdf
12:30	Sarah Perry University of Massachusetts Amherst, USA	Graphene-Based Microfluidics for Serial Crystallography	htm	pdf

13:00-14.00 Lunch buffet

S6 - Crystal to beam		chair: Dominik Obertuer
14:00	Alke Meents DESY, Hamburg	A low background sample holder for fixed target serial crystallography experiments	htm	pdf
14:30	Uwe Weierstall Arizona State University, AR, USA	Microcrystal sample delivery for serial crystallography in a high viscosity medium	htm	pdf
15:00	Christian Betzel University of Hamburg, Germany	Distinguishing Protein Nanocrystals from Amorphous Precipitate by Depolarized Dynamic Light Scattering	htm	pdf
15:30	Allen Orville Diamond Light Source, Didcot, UK	Acoustic droplet ejection: from crystallization through time-resolved SFX	htm	pdf
16:00	Vernon Smith Bruker	The changing role of in-house crystallography	htm	pdf
16:20	Coffee, refreshment

		chair: Naomi Chayen
18:45	Ada Yonath Weizmann Institute of Science, Rehovot, Israel	The Recent Resolution Revolution & Friendly Medicine	htm	pdf
20:30	Concert Ars Instrumentalis Pragensis	cinema hall of hotel Pyramida	PDF programme

Tuesday, July 5

S7 - Chemistry of crystallization		chair: Naomi Chayen
8:30	Terese Bergfors Uppsala University, Sweden	Strategies and stories for the small-scale crystallization laboratory	htm	pdf
9:00	Emmanuel Saridakis Institute of Nanoscience and Nanotechnology, National Centre for Scientific Research ‘Demokritos’ in Athens, Greece	Thermodynamic stabilization, entropy, and crystallization of proteins	htm	pdf
9:30	Lisza M. Bruder University of Lethbridge, Lethbridge, Canada	Glycerol alters substrate binding in PTPLP:IP complexes	htm	pdf
9:50	Jindřich Hašek Institute of Biotechnology, Czech Academy of Sciences, Vestec	Controlling the crystal growth. Why is poly(ethyleneglycol) the most effective precipitant for protein crystallization?	htm	pdf
10:10	Alexander McPherson University of California, Irvine, CA, USA	Experiments on the Diffusion of Dyes and Ions into Protein Crystals	htm	pdf
10:30	Break, refreshment

S8 - Complementary methods		chair: Claude Sauter
11:00	Eric Ennifar Architecture et Réactivité de l’ARN, Université de Strasbourg, IBMC, CNRS, Strasbourg, France	ITC-assisted crystallization of protein-ligand complexes	htm	pdf
11:30	Hartmut Luecke University of California, Irvine, CA, USA	Membrane Protein Crystallization Using Cubic Lipid Phases, Bicelles and Vapor Diffusion	htm	pdf
12:00	Abel Moreno Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico	Myths and realities about the influence of electric and magnetic fields on protein crystallization and protein crystal growth	htm	pdf
12:20	Marko Ristic CSIRO Manufacturing Biomedical, Melbourne, Australia	Computational tools to aid crystallization	htm	pdf
12:40	Thomas Jocks Wyatt Technology EU	How light scattering techniques can contribute to purification, characterization and crystallization of proteins	htm	pdf

13:00-14.00 Lunch buffet

S9 - Scoring methods		chair: Jeroen Mesters
14:00	Janet Newman SCIRO Parkville, Australia	What’s in a drop? Moving from images to outcomes	htm	pdf
14:30	Julie Wilson University of York, UK	Automated scoring of crystallization experiments using multiple images	htm	pdf
15:00	Samyam Acharya University of Alabama, Huntsville, AL, USA	A genetic algorithm for the optimization of protein crystallization screening	htm	pdf
15:20	Angela Criswell Rigaku Oxford Diffraction	An add-on device for automated in situ diffraction screening	htm	pdf
15:40	Break, refreshment

S10 - Teaching macromolecular crystallization		chair: Juan Manuel Garcia-Ruiz
16:10	Claude Sauter University of Strasbourg, ARN - IBMC - CNRS, Strasbourg, France	Biological crystallization: from the classroom to the bench	htm	pdf
16:40	Martin Caffrey Trinity College, Dublin, Ireland	A Laboratory Course on Crystallizing Membrane and Soluble Proteins and Complexes by the Lipid Cubic Phase (In Meso) Method	htm	pdf
17:10	Stephane Veesler CINaM - CNRS, Aix-Marseille Université, Marseille, France	Teaching (macromolecular) crystallization with movies	htm	pdf
17:30	Monika Spano Institut de Biologie Structurale (Université Grenoble Alpes), France	Optimization of Crystallization using Dialysis Combined with Temperature Control	htm	pdf
17:50	Juan Manuel Garcia-Ruiz CSIC-University of Granada, Granada. Spain	Teaching protein crystallization at the Laboratory for Crystallographic Studies (Granada, Spain)	htm	pdf

18:30-20.00		Poster session II
20:00-22.00		IOCBr meeting

Wednesday, July 6

		chair: Jose A. Gavira
8:30	Juan Manuel Garcia-Ruiz Laboratorio de Estudios Cristalográficos IACT, (CSIC-UGR), Granada, Spain	The impact of crystals in art and mind	htm	pdf

S11 - Crystallization methods for neutron diffraction		chair: Monika Budayová-Spano
9:20	Shigeru Sugiyama Osaka University, Japan	Development of protein seed crystals reinforced with high-strength hydrogels	htm	pdf
9:50	Matthew P. Blakeley Institut Laue Langevin, Grenoble, France	Neutron cryo-crystallography: methods, applications and challenges	htm	pdf
10:20	Flora Meilleur North Carolina State University, Neutron Sciences, Oak Ridge National Laboratory	Crystallization of a glycosylated protein, protein expressed with Pichia pastoris, for neutron crystallography
10:50	Niels Junius Institut de Biologie Structurale, CEA-CNRS-UGA,Universite Grenoble Alpes, France	Crystallization with an automated apparatus for temperature-controlled flow-cell dialysis with real-time visualization	htm	pdf
11:10	Break, refreshment

		chair: Juan Manuel Garcia Ruiz
11:40	Richard Giège IBMC du CNRS, Strasbourg, France	What biocrystallogenesis tells us – What is needed in the future	htm	pdf

12:30-14.00 Lunch buffet


15:00	Special conference train to Pilsen	departure from Prague main railway station 15:12
17:00	Conference dinner and excursions to the brewery	Pilsen brewery
22:15		return from Pilsen 21:09

Thursday, July 7

S12 - Theory and practice of crystallization		chair: Jindřich Hašek
8:30	Peter Vekilov University of Houston, TX, USA	Are the protein pre-nucleation clusters equilibrium structures or irreversible aggregates?	htm	pdf
8:50	David Hargreaves Astra Zeneca, Cambridge, UK	Antibodies as Chaperones in Crystallization: Parameters for Success	htm	pdf
9:10	Jose Antonio Gavira Laboratorio de Estudios Cristalograficos, IACT (CSIC-UGR), Granada, Spain	Protein crystallization in hydrogels, current status and future prospect	htm	pdf
9:30	Paul Thaw TTP Labtech	Flying through optimization screening with dragonfly	htm	pdf
9:50	Ľubica Urbáníková Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia	Protein crystallization - tricks and practice	htm	pdf
10:10	Guillermo Calero University of Pittsburgh, PA, USA	Transmission electron microscopy for the evaluation and optimization of crystal growth	htm	pdf
10:30	Break, refreshment

S13 - Crystallization in industry and biomedicine		chair: Bernhard Rupp
11:00	Allan D’Arcy Actelion Pharmaceuticals, Switzerland	A rational approach to crystallizing proteins in the pharmaceutical industry, the impact of micro seed matrix seeding	htm	pdf
11:30	Linda Oster Landgren Astra Zeneca, Gothenburg, Sweden	Successful generation of structural information for fragment-based drug discovery	htm	pdf
11:50	Thomas Peignier Space Applications Services, Zaventem, Belgium	XRayLab: an X-ray diffraction facility for the International Space Station dedicated to the study of space-grown crystals	htm	pdf
12:10	Hai Hou Northwestern Polytechnical University, Xi'an, China	A comparative study on the diffraction quality of protein crystals obtained using the cross-diffusion microbatch and sitting-drop vapor diffusion methods	htm	pdf

12:30-13.30 Lunch buffet

S14 - Ionic liquids in protein crystallization		chair: Babak Minofar
13:30	Magdalena Kowacz Polish Academy of Sciences, Crakow, Poland	Ionic liquids (ILs)-water interplay in protein crystallization. From IL additives to nucleants to…	htm	pdf
14:00	Marc Pusey iXpressGenes Inc., Huntersville, USA	Ionic liquids as protein crystallization additives	htm	pdf
14:30	Dominique Maes Vrije Universiteit Brussel, Belgium	How camels can aid crystallization? The challenges of the de novo designed protein Octarellin.	htm	pd
14:50	Patrick Charbonneau Duke University, Durham, NC, USA	Water in Protein Crystals	htm	pdf
15:10	Edward Petri Faculty of Sciences, University of Novi Sad, Serbia	Use of X-ray crystallographic data for computational modeling of receptor-ligand interactions: design of steroidal inhibitors of breast and prostate cancer cell growth	htm	pdf
15:30	Announcement of poster prizes, closing

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	Keynote lectures
	Speakers invited for sessions
	Contributed talks (selected from abstracts)
	Company talks