Programme HEC-24

Thursday, September 22

12:00-15.00 Registration

15:00-15.15 Welcome and opening remarks (Ivana Kutá Smatanová)

15.15	Przemek Grudnik Jagiellonian University in Krakow, Poland		Presentation of new HEC group
Session I: MX / Cryo-EM STRUCTURES, BACTERIAL ENZYMES AND REGULATORS			Chairs: Wulf Blankenfeldt, Milton T. Stubbs
		Group
15.30	Anna Cociurovscaia Lodz University of Technology, Poland	Bujacz	Crystal structures of copper sensing bacterial histidine kinase
15.45	Michael Krummhaar Max Planck Institute of Colloids and Interfaces, Potsdam, Germany	Roth	Structural and functional investigations into Glycocin-Glycosyltransferases
16.00	Daniela Gjorgjevikj Freie Universität Berlin, Germany	Wahl	Inhibition of a bacterial global gene regulator by a phage protein via forced hyper-oligomerization
16:15	Rezan Amjadi Medical University of Innsbruck, Austria	Scheffzek	High-resolution structure of human nucleoside diphosphate kinase C in complex with different nucleotides
16:30	Elzbieta Wator Jagiellonian University, Krakow, Poland	Grudnik	Half way to hypusine. Molecular basis of (deoxy)hypusination
16:45	Carl Helmer Freie Universität Berlin, Germany	Wahl	High-resolution structure analysis of a small plant biocatalyst at sub 2 Å resolution by Cryo-EM
17:00	Ruben Ananian Max Planck Institute of Colloids and Interfaces, Berlin, Germany	Roth	First insights into the structure and function of the human glycogen debranching enzyme

17.05 Break, refreshment

Session II: INFECTION AND DISEASES		Group	Manfred Weiss, Norbert Straeter
17:30	Johannes Schweininger Universität Erlangen-Nürnberg, Germany	Muller	Towards understanding and inhibiting the hook-into-groove interaction of the herpesviral nuclear egress complex
17:45	Petra Havlíčková Faculty of Science, University of South Bohemia, Czech Republic	Kutá Smatanová	Crystal structure of Smolstatin – protease inhibitor from the myxozoan parasite Sphaerospora molnari
18:00	Chuan Qin University of Greifswald, Germany	Lammers	Structural and biochemical characterization of the histone deacetylase-like amidohydrolase from Klebsiella pneumoniae
18:15	Lena M. Grass Freie Universität Berlin, Germany	Wahl	Architecture and functional dynamics of a large, virulence-associated DNA helicase from enterohaemorrhagic Escherichia coli
18:30	Marta Gapinska International Institute of Molecular and Cell Biology in Warsaw, Poland	Nowotny	Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases
18:45	Magdalena Gawel Institute of Bioorganic Chemistry, Polish Academy of Sciences. Poland	Brzezinski/ Jaskolski	Identification of selective inhibitors of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa via high-throughput screening and crystallographic approaches
18:50	Laila S. Benz Helmholtz-Zentrum Berlin, Germany	Weiss	New chemical entities for modulating SARS-CoV-2 activity
18:55	Zhennan Tian Freie Universität Berlin, Germany	Wahl	Structural basis of co-transcriptional rRNA folding and processing
19:00	Vernon Smith Bruker	Exhibitor	Getting it right from the start – Collecting better data with the D8 VENTURE

19.30 Welcome dinner

21.00 Bar

Friday, September 23

7.00 Breakfast

Session III: DRUG DESIGN		Group	Mariusz Jaskolski, Jan Dohnálek
9.00	Martin Malý Institute of Biotechnology, Czech Academy of Sciences, Vestec	Dohnálek	Integrative structural study of antibiotic-inactivating enzyme from Stenotrophomonas maltophilia
9.15	Anna Katharina Kottwitz Fraunhofer Institute for Cell Therapy and Immunology IZI, Halle, Germany	Linnert	Development of monoclonal antibodies against 3-Nitrotyrosine-Abeta suspected of being associated with Alzheimer’s disease
9.30	Stefan Djukic Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic	Řezáčová	Structural studies of human purine nucleoside phosphorylase inhibitors
9.45	Zdeněk Vavřina Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic	Řezáčová	Structure- and Activity-Guided Drug Design of 7-Deazapurine Cyclic Dinucleotide Analogues Activating Stimulator of Interferon Genes (STING) Receptor
10.00	Maria Kehr University of Bayreuth, Germany	Steegborn	Structural studies on second generation soluble adenylyl cyclase inhibitors and characterization of a putative ATPase domain

10.15 Break, refreshment

10.45	Andrea Smith Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic	Řezáčová	New protein reactive centres against aspartic proteases
10.50	Tingting Wang Freie Universität Berlin, Germany	Wahl	Structural basis of promoter melting in Spirochaeta africana

10.55	Felix Hennersdorf Rigaku	Exhibitor	Rigaku Advances in X-ray and Electron Crystallography
11.05	Rastislav Ošťádal Thermofisher	Exhibitor	Tundra, an affordable microscopy for sample screening to high resolution structures
	HEC-24 lecture
11.15	Kay Diederichs University of Konstanz, Germany	Plenary	A better understanding of X-ray data quality indicators

12.30 Lunch

14.30 Boat trip at Lipno lake

16.00 Refreshment

Session IV: FRAGMENT SCREENING, PROTEIN DESIGN		Group	Cyril Bařinka, Matthias Bochtler
16.30	Keerthiraju E Ravichandran Jagiellonian University, Krakow, Poland	Glatt	E2/E3-independent ubiquitin-like protein conjugation by Urm1 protects the proteome under oxidative stress
16.45	Shivam Shukla Institute of Biotechnology, Czech Academy of Sciences, Vestec	Bařinka	In-solution structure and oligomerization of human histone deacetylase 6 - an integrative approach
17.00	Kinga Pokrywka Institute of Bioorganic Chemistry, Poznan, Poland	Jaskolski	Structural Studies Of Rhizobium Etli Inducible Asparaginase Mutants
17.15	Paula Fröling Helmholtz-Zentrum Berlin, Germany	Weiss	Structural analysis of metabolic binding partners of SuhB
17.30	Tim B. Garbers University of Goettingen, Germany	Ficner	Crystallographic fragment screen on the c-di-AMP synthesizing enzyme CdaA Dominic
17.45	Mark Kriegel Universität Erlangen-Nürnberg, Germany	Muller	The implementation of explicit water molecules in side chain packing algorithms for protein design
18.00	Florian Grau Cytiva	Exhibitor	ÄKTA go™—Redefining Routine Protein Purification

18.15 Dinner

Session V: NUCLEASES AND RECEPTORS		Group	Christian Roth, Markus Wahl
19.45	Linh H. Tran Institute of Bioorganic Chemistry, Poznan, Poland	Ruszkowski/ Jaskolski	3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula
20.00	Fabian Pohl Leipzig University	Straeter	ADGRB2 and its Resistance to Autoproteolysis
20.15	Kristýna Adámková Institute of Biotechnology, Czech Academy of Sciences, Vestec	Dohnálek	Structural analysis of S1-like nuclease from opportunistic biofilm dwelling pathogen Stenotrophomonas maltophilia
20.30	Philipp Galuska Max Perutz Labs, Vienna, Austria	Djinovic-Carugo	Liquid-liquid phase separation and its role in Z-Disc formation
20.45	Katarzyna Krakowska International Institute of Molecular and Cell Biology, Warsaw, Poland	Bochtler	Structural analysis of the BisI family modification dependent restriction endonucleases
20.50	Blanka Husťáková Institute of Biotechnology, Czech Academy of Sciences, Vestec	Dohnálek	Crystallographic study reveals an unexpected substrate for S1-P1 nuclease
20.55	Jakub Hrubý Institute of Biotechnology, Czech Academy of Sciences, Vestec	Dohnálek	Effects of the Zn(II) to Cd(II) Exchange on the Structure and Activity of S1 Nuclease

21.10 HEC committee meeting

21.10 Bar

Saturday, September 24

7.00 Breakfast

Session VI: STRUCTURE DETERMINATION and MOLECULAR MECHANISM - postdoc talks		Group	Michael Lammers, Miriam Linnert
9.30	Sergio Romero-Romero University of Bayreuth, Germany	Hoecker	Navigating the structural and stability landscape of de novo TIM barrels by protein design and engineering
9.45	Abibe Useini Leipzig University, Germany	Straeter	Interference of environmental compounds with PPARgama
10.00	Alaa Shaikhqasem Martin Luther University Halle-Wittenberg, Germany	Stubbs	Structure determination of a protein-peptide complex using microcrystal electron diffraction

10.15 Break, refreshment

10.40	Anton Slyvka International Institute of Molecular and Cell Biology, Warsaw, Poland	Bochtler	Activity and structure of human (d)CTP specific deaminase CDADC1
10.55	Gert Weber Helmholtz-Zentrum Berlin, Germany	Weiss	Structures of a DYW domain shed first light on a unique plant RNA editing regulation principle

11.00 Hybrid congress IUCr-25 in Prague 2021 - statistics of attendance of bio-crystallographic lectures and sessions (Radomír Kužel)

11.10 Announcement of HEC25 (Michael Lammers)

11.20 HEC prize and closing remarks

11.30 Lunch