I will tell you what are my memories of twenty years of Discussions in Structural Molecular Biology. I will try to explain the greatest mysteries of this conference: why in March, why in Saturday, why in Nové Hrady? I will also show programs, lists of participants, abstracts from the historically first meetings. These existed as html pages (Internet, yes!) and I found most of them beginning with the files from the first year in 2002. I also have pictures from some years and selected ones will be presented in spite of GDPR. PDB permitting, I plan to show (surely growing) numbers of experimental structures Made in Czech Republic and comment on changing focus from a lot of computer modeling at the beginning to mostly experimental structural biology in recent years.