Structural mass spectrometry (MS3D) is a fast growing field on analytical chemistry representing a new approach for protein structural studies. In CMS, the tools of structural mass spectrometry, including native mass spectrometry, hydrogen-deuterium exchange, chemical cross-linking and other labelling method, are well established and allow to look beyond the edge of traditional structural techniques. The structural mass spectrometry core facility is equipped with state-of-the-art instrumentation such 15T FT-ICR, timsToF Pro, timsToF CSP, automation system for HDX, UPLC and nanoUPLC systems. Besides the MS3D, the core facility offers other services including identification and quantification of proteins, precise determination of protein molecular mass, characterization of various posttranslational modifications (phosphorylation, glycosylation, acetylation …).
CIISB, Instruct-CZ Centre of Instruct-ERIC EU consortium, funded by MEYS CR infrastructure project LM2018127 and European Regional Development Fund-Project „UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974), is gratefully acknowledged for the financial support of the Structural mass spectrometry core facility.