The core facilities for structural biology in BIOCEV are organized under the
Centre of Molecular Structure, run by the Institute of Biotechnology, Czech
Academy of Sciences and belong to the Czech Infrastructure for Integrative
Structural Biology. The Centre of Molecular Structure (CMS) encompasses several
laboratories providing a complex approach to studies of three-dimensional
structure, function and biophysical properties of biological molecules.
The BIOCEV building is located just outside of Prague. It can be easily reached by car or public transport.
The range of instruments offered by CMS has recently been extended to include several other important techniques, like SONICC (Formulatrix), timsTOF pro (Bruker Daltonics), or Vitrobot (Thermo Scientific). SONICC enables detection of extremely thin crystals, microcrystals smaller than 1 μm, and crystals obscured in birefringent LCP. New mass spectrometer timsTOF can be used for high throughput shotgun proteomics, hydrogen-deuterium exchange, covalent labelling experiments, and native mass spectrometry with ion mobility separation. Vitrobot is a new tool for preparation of samples suitable for electron diffraction and cryoEM experiments.
The services of CMS are offered in open access regime and users can apply for access via https://www.ciisb.org/ and https://instruct-eric.eu/centre/biocev/.
The Centre of Molecular Structure is supported by: MEYS CR (LM2018127); project Czech Infrastructure for Integrative Structural Biology for Human Health (CZ.02.1.01/0.0/0.0/16_013/0001776) from the ERDF; UP CIISB (CZ.02.1.01/0.0/0.0/18_046/0015974), and ELIBIO (CZ.02.1.01/0.0/0.0/15_003/0000447).