Tau generates protective envelopes on microtubules
Zdeněk Lánský
Institute of Biotechnology, Czech Academy of
Sciences, BIOCEV
Tau is an intrinsically disordered microtubule-binding
protein involved in a number of neurodegenerative diseases. Malfunction of tau
and its detachment from axonal microtubules is correlated with axonal
degeneration. However, mechanistic understanding of this process is still
missing. Employing in vitro reconstitution approach combined with single
molecule imaging, we recently showed that tau molecules cooperatively form
cohesive, selectively permeable envelopes on the microtubule surface. We found
that the formation of tau envelopes is governed by structural changes in the
microtubule lattice. Importantly, these tau envelopes can protect microtubules
from microtubule-degrading enzymes. I will discuss the mechanism of the tau
envelope formation and the effect of established neurodegenerative factors on
the envelope structure and stability.