LYS735 PARITICIPATES ON THE ATP BINDING TO THE ISOLATED C-TERMINUS TRPV1
L. Gryčová, Z Lánský, E. Friedlová, J Teisinger
Institute of Physiology, Academy of Sciences of Czech Republic, 142 00 Praha
Transient receptor potential channel vanilloid receptor 1 (TRPV1) is member of TRP ion channel family. TRPV1 is responsible for a heat and chemical – evocated pain responses and it could be activated by vide range of chemical stimuli. Its activity is modulated by intracellular ATP, by direct interaction with ATP binding domains. Despite missing experimental evidence of the tertiary structure, TRPV1 is predicted to be composed of six transmembrane domains, short hydrophobic stretch that line the pore region and two cellular terminuses.
In this study, we have tested the ability
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This work was supported by Grant GAAV IAA600110701, GACR 303/07/0915, project (No. H148), Center for Neurosciences No. LC554 MSMT CR, and Research Project No. AVOZ 50110509.