MS details

The schedule is available at https://www.conftool.com/iucr2020/

Fragment Screening, LCP, and Automation

Comments

The increasing speed of detectors and the ever increasing automation and beam intensities at synchrotrons have made it possible to collect several hundred diffraction data sets within 24 hours of beam time. This had made extensive screening-by-crystallography experiments feasible. Fragments can be screened for binding in early-stage drug discovery approaches, metabilites can be screened for functional investigations, etc. Such experiments also require a different way of thinking about individual diffraction data sets. In a screening campaign consisting of several hundred data sets, the individual data sets are essentially meaningless. The power of such an experiments lies in the simultaneous analysis of all data sets at once.

Chair persons

Name	Family	Institution	City	Country	Region
Lisa	Keefe	Argonne National Laboratory	Argonne	USA	ACA
Alice	Douangamath	Diamond Light Source Ltd	Oxfordshire	UK	ECA

Invited speakers

Name	Family	Institution	City	Country	Title
Stephen M.	Soisson	Merck & Co.	West Point, PA	USA
Martin	Noble	University of Newcastle upon Tyne	Newcastle	UK	FragLites: a library of small molecules incorporating anomalous scatterers with applications in screening and protein interaction mapping