CYCLOSPORINS P2₁ - NEW FAMILY OF CLATHRATES

Michal Hušák¹ ,Svetlana Pakhomova¹, Alexandr Jegorov² , Bohumil Kratochvíl¹, Zdirad Zák ³, Ivana Císarová⁴, Ladislav Cvak², Martin Buchta²

¹ Department of Solid State Chemistry, Prague University of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic, e-mail:husakm@vscht.cz
² Galena Co., Research Unit, Branišovská 31, 370 05 Ceské Budejovice, Czech Republic
³ Department of Inorganic Chemistry, Masaryk University, Kotláoská 2, 611 37 Brno, Czech Republic
⁴ Department of Inorganic Chemistry, Charles University, Albertov 6,128 43 Prague, Czech Republic

Keywords: Cyclosporin, Clathrates

Cyclosporins P2₁ are described as new class of clathrates. The crystal structure determination of the following structures is reported:

Cyclosporin A . dimethylisosorbide (ambient temperature) [1]

Cyclosporin A . tetrahydrofurane (ambient temperature)

Cyclosporin A . di-n-butylether (ambient temperature)

Cyclosporin A . di-n-butylether (ambient temperature)

Cyclosporin A . di-n-butylether ( 150K )

Cyclosporin E . acetone . water (ambient temperature) [2]

Cyclosporin E . 2-butanol ( 150K )

The shape of the cavity inside the structure of cyclosporin A . dimethylisosorbide is visualized on following picture.

1. M. Hušák, B. Kratochvíl, A. Jegorov, V. Ma?ha, M. Stuchlík, T. Andrýsek, Z. Kristallogr. 211 (1996) 313-318.
2. M. Hušák., B. Kratochvíl, M. Buchta, L. Cvak, A. Jegorov, Coll. Czech. Chem. Commun. 63 (1998) 115-120.