OPTIMISATION OF CCD DETECTOR SYSTEMS FOR NON-ROUTINE APPLICATIONS IN BIOLOGICAL AND CHEMICAL CRYSTALLOGRAPHY

Susan K. Byram¹ and E.R. Hovestreydt²

¹ Bruker-AXS Inc., 6300 Enterprise Lane, Madison, WI 53719 Email: sbyram@bruker-axs.com
² Bruker-AXS GmbH, Rheinbrückenstr, 76181 Karlsruhe, Email: eric.hovestreydt@bruker-axs.de

CCD detector systems, first introduced by Bruker AXS (as Siemens) in 1993, are now available in different sensitivities and sizes - 1K, 2K, Mosaic - coupled with different X-ray optics to be used on sealed tube generators, rotating anode generators, and synchrotron sources.

Advances in detector design, X-ray optics, X-ray sources and software algorithms will be presented, with examples of how different systems are optimised to handle challenging research problems, including:

• microcrystals of chemical and biological compounds
• weakly diffracting organic compounds
• large unit cell problems
• twinned or split samples
• charge density studies